Highlights

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drugs and sex are often inextricably linked. Drugs reduce sexual inhibitions, which are often caused by feelings of shame, trauma, or body dysmorphia.

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When inhaled, they quickly relax involuntary smooth muscle. They also act as vasodilators that widen blood vessels, lowering blood pressure and increasing blood flow throughout the body. That surge of blood means extra oxygen and causes a head rush which, along with the release in muscle tension, leads to the giddy high Mother Superior Mary Regina so elegantly depicted.ADVERTISEMENTPoppers have added physical benefits for penetrative sex: The human reproductive tract is built by smooth muscle, and the anal sphincter, while voluntarily controlled, is surrounded by smooth muscle that can make penetration easier when it’s relaxed. For many men who have sex with men, poppers have obvious practical applications.

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minority stress, wherein stigmatized groups experience psychological pain through harassment, discrimination, and related experiences that puts them at high risk for physical and mental health issues. “That creates situations where we drink more, we do drugs more, we have sex more,” he says. “We sort of are in these spaces that allow us to seize some forms of pleasure and take some power from that.”

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bottles helped disco-goers achieve a type of “collective effervescence,” a sociological term for when a group of people come out of themselves together.

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People routinely talk about telling very intimate details of their lives and having very deep conversations with people they barely know, because they did drugs together or had sex in the same space

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Poppers may cause a brief period of euphoric wooziness, but they affect the body differently than other volatile chemical inhalants (i.e. sniffing glue or paint). The former interact with smooth muscle, while the latter directly target the brain and nervous system

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Using an excessive amount at once (usually by drinking them, which is a terrible idea) can cause potentially fatal methemoglobinemia, which is when the blood’s hemoglobin fails to properly carry oxygen.

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“poppers maculopathy,” referring to eye damage caused by the use of a specific type of alkyl nitrite—isopropyl nitrite

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irritation and burning upon contact with skin. Regular users may exhibit what some call “poppers nose,” when scaly, irritated skin forms around the nostrils after too many close calls with the bottle’s surface.

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highly flammable: A massive 1981 fire in San Francisco may have started at a warehouse full of poppers.

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not addictive (though users can build up a tolerance), they don’t cause AIDS, and their effects don’t last more than a minute or so

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included language to classify alkyl nitrites as a drug unless they were produced and marketed for some purpose other than human consumption. That’s why they now have labels that say “room odorizer” or “leather cleaner

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Because they’re associated for a lot of people so closely with sex and gay sex in particular, I think they do have a more illicit reputation